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đŸ”„ Cancer Researcher Drops Ivermectin Bombshell đŸ”„

A new cancer treatment protocol involving repurposed drugs Ivermectin (commonly known as a ‘horse dewormer’), Fenbendazole (a ‘dog dewormer’), and Mebendazole has recently passed peer review and is being heralded as a potential breakthrough in cancer therapy.

According to the Public Library of Science (PLOS), a research protocol is a detailed study design or set of instructions for carrying out a specific experimental process or procedure.

The hybrid orthomolecular protocol, featured in the Journal of Orthomolecular Medicine (Vol. 39.3), targets the mitochondrial-stem cell connection (MSCC), a key mechanism believed to drive cancer stem cells and tumor progression.

Dr. William Makis, a nuclear medicine physician and researcher specializing in multiple medical fields, including cancer and one of the first doctors to warn about the danger of the COVID shot, shared this news in a post on X.

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Vigilant News Network
Vigilant News Network
HealthCancer Researcher Drops Ivermectin Bombshell
‘Horse dewormer’ strikes back in shocking turn of events.

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Published 41 seconds ago on October 14, 2024By The Gateway Pundit

This article originally appeared on The Gateway Pundit and was republished with permission.

Guest post by Jim Hoft

A new cancer treatment protocol involving repurposed drugs Ivermectin (commonly known as a ‘horse dewormer’), Fenbendazole (a ‘dog dewormer’), and Mebendazole has recently passed peer review and is being heralded as a potential breakthrough in cancer therapy.

According to the Public Library of Science (PLOS), a research protocol is a detailed study design or set of instructions for carrying out a specific experimental process or procedure.

The hybrid orthomolecular protocol, featured in the Journal of Orthomolecular Medicine (Vol. 39.3), targets the mitochondrial-stem cell connection (MSCC), a key mechanism believed to drive cancer stem cells and tumor progression.

Dr. William Makis, a nuclear medicine physician and researcher specializing in multiple medical fields, including cancer and one of the first doctors to warn about the danger of the COVID shot, shared this news in a post on X.

BREAKING NEWS: First-in-the-World Ivermectin, Mebendazole and Fenbendazole Protocol in Cancer has been peer-reviewed and published on Sep.19, 2024!

The future of Cancer Treatment starts NOW.

My thanks to lead authors Ilyes Baghli and Pierrick Martinez for their incredible inspired work, FLCCC’s Dr.Paul Marik for his extensive work on repurposed drugs and every co-author who worked hard to bring this paper to life.

I hope that this peer-reviewed paper lays the groundwork for a brand new future for Cancer Treatment.

Many of you know that I have been helping thousands of Cancer patients with high dose Ivermectin, Mebendazole, and Fenbendazole.

We are already starting to see incredible successes with these repurposed drugs.

Mainstream Oncology collapsed after the rollout of contaminated COVID-19 mRNA Vaccines.

Most Oncologists abandoned their Hippocratic Oath, gave contaminated mRNA Vaccines to all their cancer patients and took the mRNA jabs themselves.

Some Oncologists have now developed mRNA Induced Cardiac arrests, blood clots and Turbo Cancer. Others have already died suddenly.

These Oncologists buried their heads in the sand and abandoned everything that it takes to be a good competent doctor.

However, there are doctors who are blazing a new path into the future. See you there!

The protocol combines existing therapies with “repurposed” drugs like ivermectin and benzimidazole derivatives (fenbendazole and mebendazole).

This strategy is based on the mitochondrial-stem cell connection (MSCC) theory, which posits that cancer originates from impaired mitochondrial function in stem cells, leading to the formation of highly tumorigenic cancer stem cells (CSCs).

These CSCs are believed to drive tumor recurrence and metastasis and exhibit resistance to conventional therapies.

According to the publication, ivermectin, fenbendazole, and mebendazole each exhibit anticancer properties through distinct yet complementary mechanisms. Ivermectin, an antiparasitic agent, induces apoptosis in cancer cells by modulating mitochondrial function and inhibiting critical pathways such as glycolysis. It has shown significant efficacy in shrinking tumor volumes in various cancer types, including pancreatic cancer, when used alone or in combination with other agents.

Fenbendazole and mebendazole, originally used as veterinary antiparasitic agents, have shown promise as anticancer agents by disrupting microtubule formation, inhibiting glucose metabolism, and inducing apoptosis specifically in cancer cells.

Both drugs have been demonstrated to reduce tumor growth and improve survival in preclinical cancer models, often surpassing traditional chemotherapy in efficacy​. However, only Mebendazole is FDA-approved for use in humans.

Joe Tippens, an Oklahoma man, recounts how he believes he cured his aggressive cancer using fenbendazole, a deworming medicine typically reserved for dogs, according to KOCO.

Tippens claims his life was saved after being advised by a veterinarian to try the dog dewormer as a last-ditch effort to fight his small-cell lung cancer, which had spread to his organs and bones.

Describing his experience, Tippens explained how his doctors gave him mere months to live, urging him to call hospice and prepare for the worst. “Once that kind of cancer goes that far afield, the odds of survival are less than 1 percent,” Tippens shared in the video. At his lowest point, he had dropped from 220 pounds to 110 pounds, saying he looked like “a skeleton with skin hanging off.” In January 2017, he began taking fenbendazole, combined with vitamin E supplements and CBD oil, which he believes led to a near-miraculous remission of his cancer within just three months.

Facebook fact-checkers have flagged the video as misleading, citing the lack of scientific evidence supporting fenbendazole as a cancer cure.

According to the protocol released recently, initial results suggest that combining ivermectin, fenbendazole, and mebendazole within this protocol may offer improved survival outcomes, especially when integrated with dietary interventions such as ketogenic diets, which reduce cancer cell fuel sources. Early case reports have shown positive responses, including tumor size reduction and disease stabilization in advanced-stage patients who had exhausted other options​.

According to the peer-reviewed protocol:

Ivermectin

An anti-parasitic derived from a bacteria called Streptomyces avermitilis, Ivermectin has anti-cancer properties and induces autophagy and apoptosis of cancer cells (Liu, et al., 2020). Ivermectin has shown a significant impact on various cancer cell lines (Juarez, et al., 2020), inducing apoptosis in cancer cells in vivo (Sharmeen, et al., 2010) and significantly reducing tumor volume compared to a control (Juarez, et al., 2020).

It induces apoptosis in cancer cells through mitochondrial mediation (Juarez, et al., 2018; Tang, et al., 2021). Ivermectin can target and regulate the pyruvate kinase muscle isoforms at the last step of glycolysis (Li, et al., 2020). It can inhibit glycolysis inducing autophagy (Feng, et al., 2022), and have a selective pro-oxidant effect on cancer cells (Wang, et al., 2018).

Search
Vigilant News Network
Vigilant News Network
HealthCancer Researcher Drops Ivermectin Bombshell
‘Horse dewormer’ strikes back in shocking turn of events.

Share this:
XFacebookEmailTelegramTwitter
Published 41 seconds ago on October 14, 2024By The Gateway Pundit

This article originally appeared on The Gateway Pundit and was republished with permission.

Guest post by Jim Hoft

A new cancer treatment protocol involving repurposed drugs Ivermectin (commonly known as a ‘horse dewormer’), Fenbendazole (a ‘dog dewormer’), and Mebendazole has recently passed peer review and is being heralded as a potential breakthrough in cancer therapy.

According to the Public Library of Science (PLOS), a research protocol is a detailed study design or set of instructions for carrying out a specific experimental process or procedure.

The hybrid orthomolecular protocol, featured in the Journal of Orthomolecular Medicine (Vol. 39.3), targets the mitochondrial-stem cell connection (MSCC), a key mechanism believed to drive cancer stem cells and tumor progression.

Dr. William Makis, a nuclear medicine physician and researcher specializing in multiple medical fields, including cancer and one of the first doctors to warn about the danger of the COVID shot, shared this news in a post on X.

BREAKING NEWS: First-in-the-World Ivermectin, Mebendazole and Fenbendazole Protocol in Cancer has been peer-reviewed and published on Sep.19, 2024!

The future of Cancer Treatment starts NOW.

My thanks to lead authors Ilyes Baghli and Pierrick Martinez for their incredible inspired work, FLCCC’s Dr.Paul Marik for his extensive work on repurposed drugs and every co-author who worked hard to bring this paper to life.

I hope that this peer-reviewed paper lays the groundwork for a brand new future for Cancer Treatment.

Many of you know that I have been helping thousands of Cancer patients with high dose Ivermectin, Mebendazole, and Fenbendazole.

We are already starting to see incredible successes with these repurposed drugs.

Mainstream Oncology collapsed after the rollout of contaminated COVID-19 mRNA Vaccines.

Most Oncologists abandoned their Hippocratic Oath, gave contaminated mRNA Vaccines to all their cancer patients and took the mRNA jabs themselves.

Some Oncologists have now developed mRNA Induced Cardiac arrests, blood clots and Turbo Cancer. Others have already died suddenly.

These Oncologists buried their heads in the sand and abandoned everything that it takes to be a good competent doctor.

However, there are doctors who are blazing a new path into the future. See you there!

The protocol combines existing therapies with “repurposed” drugs like ivermectin and benzimidazole derivatives (fenbendazole and mebendazole).

This strategy is based on the mitochondrial-stem cell connection (MSCC) theory, which posits that cancer originates from impaired mitochondrial function in stem cells, leading to the formation of highly tumorigenic cancer stem cells (CSCs).

These CSCs are believed to drive tumor recurrence and metastasis and exhibit resistance to conventional therapies.

According to the publication, ivermectin, fenbendazole, and mebendazole each exhibit anticancer properties through distinct yet complementary mechanisms. Ivermectin, an antiparasitic agent, induces apoptosis in cancer cells by modulating mitochondrial function and inhibiting critical pathways such as glycolysis. It has shown significant efficacy in shrinking tumor volumes in various cancer types, including pancreatic cancer, when used alone or in combination with other agents.

Fenbendazole and mebendazole, originally used as veterinary antiparasitic agents, have shown promise as anticancer agents by disrupting microtubule formation, inhibiting glucose metabolism, and inducing apoptosis specifically in cancer cells.

Both drugs have been demonstrated to reduce tumor growth and improve survival in preclinical cancer models, often surpassing traditional chemotherapy in efficacy​. However, only Mebendazole is FDA-approved for use in humans.

Joe Tippens, an Oklahoma man, recounts how he believes he cured his aggressive cancer using fenbendazole, a deworming medicine typically reserved for dogs, according to KOCO.

Tippens claims his life was saved after being advised by a veterinarian to try the dog dewormer as a last-ditch effort to fight his small-cell lung cancer, which had spread to his organs and bones.

Describing his experience, Tippens explained how his doctors gave him mere months to live, urging him to call hospice and prepare for the worst. “Once that kind of cancer goes that far afield, the odds of survival are less than 1 percent,” Tippens shared in the video. At his lowest point, he had dropped from 220 pounds to 110 pounds, saying he looked like “a skeleton with skin hanging off.” In January 2017, he began taking fenbendazole, combined with vitamin E supplements and CBD oil, which he believes led to a near-miraculous remission of his cancer within just three months.

Facebook fact-checkers have flagged the video as misleading, citing the lack of scientific evidence supporting fenbendazole as a cancer cure.

According to the protocol released recently, initial results suggest that combining ivermectin, fenbendazole, and mebendazole within this protocol may offer improved survival outcomes, especially when integrated with dietary interventions such as ketogenic diets, which reduce cancer cell fuel sources. Early case reports have shown positive responses, including tumor size reduction and disease stabilization in advanced-stage patients who had exhausted other options​.

Continues:

https://vigilantnews.com/post/cancer-researcher-drops-ivermectin-bombshell

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👉UNIVERSAL HIGH INCOME (AKA Elon's Soft Landing)

"There is only basically one way to make everyone wealthy, and that is AI and robotics." — Elon Musk

It's called, "Universal High Income"

Elon’s concept of Universal High Income 🚀 (which he often uses instead of "Maximum" or "Basic" income) is a vision of a future where human labor is no longer a requirement for survival.

The combination of advanced AI and mass-produced humanoid robots (like Tesla’s Optimus) will break the traditional link between work and income â›“ïžâ€đŸ’„. Here is the breakdown 👇

đŸ”č From "Basic" to "High" Income 💎

While traditional Universal Basic Income (UBI) đŸ’” is often proposed as a government safety net to provide a minimum standard of living, Musk argues that AI will lead to Universal High Income (UHI) ✹

The "High" Part: He believes that in an AI-driven economy, people won't just have "enough to get by"

Instead, they will have access to a luxurious standard of living because goods and services will become incredibly cheap and abundant

Post-Scarcity: He envisions ...

00:00:06
Make The Right Choice.. 😉

Don't follow the sheep into the slaughter house, because of the FALSE illusions.

00:00:06
$318 Trillion in Debt Could Break the Silver Market

There’s one number Wall Street doesn’t want you thinking about: $318 trillion. That’s how much global debt exists right now, and my cousin Asian Guy breaks down why this debt spiral could collide with a silver market already in a multi-year supply deficit. In this video, he explains:

  • Why governments always inflate debt away

  • Why silver is facing record industrial demand and shrinking inventories

  • How paper silver is diverging from physical reality

  • Why some analysts see $100+ silver, or a system break before that

This isn’t hype. It’s math, history, and market stress signals lining up. The market hasn’t fully reacted yet. But the pressure is already there.

00:19:21
👉 Coinbase just launched an AI agent for Crypto Trading

Custom AI assistants that print money in your sleep? 🔜

The future of Crypto x AI is about to go crazy.

👉 Here’s what you need to know:

💠 'Based Agent' enables creation of custom AI agents
💠 Users set up personalized agents in < 3 minutes
💠 Equipped w/ crypto wallet and on-chain functions
💠 Capable of completing trades, swaps, and staking
💠 Integrates with Coinbase’s SDK, OpenAI, & Replit

👉 What this means for the future of Crypto:

1. Open Access: Democratized access to advanced trading
2. Automated Txns: Complex trades + streamlined on-chain activity
3. AI Dominance: Est ~80% of crypto 👉txns done by AI agents by 2025

🚹 I personally wouldn't bet against Brian Armstrong and Jesse Pollak.

👉 Coinbase just launched an AI agent for Crypto Trading
🚹This Is HUGE! (THINK FREE ENERGY)😉

This is only the beginning👇and I know this sounds insane, but believe it or not, it's still true-> This came from reverse engineering so called Alien TechnologiesđŸ‘œđŸ›žPresident Donald Trump’s media company, Trump Media & Technology Group (TMTG), announced on December 18, 2025, a definitive agreement to merge with TAE Technologies, a nuclear fusion company founded in 1998, in an all-stock transaction valued at more than $6 billion. The merger aims to create one of the world’s first publicly traded fusion energy companies and is intended to support America’s technological and energy dominance, particularly in powering the artificial intelligence revolution.

Under the terms of the deal, shareholders of both companies will each own approximately 50% of the combined entity on a fully diluted basis. Trump Media has agreed to provide TAE Technologies with $300 million in cash to advance its fusion technology development, including $200 million at signing and an additional $100 million upon regulatory ...

🚹 Russia clears digital ruble for government usage starting January 2026 🚹

Russia’s retail CBDC launch has been postponed to September 2026, but federal government departments will be authorized to use the digital ruble for public-sector payments beginning 1 January 2026, according to a Ministry of Finance directive published last week. The move marks the first live deployment of Russia’s CBDC, albeit in a limited government-only pilot, and introduces programmable features that can restrict how recipients spend funds.

🔑Key points

đŸ”č Retail delay: Consumer launch pushed back from 1 July 2025 to 1 September 2026; no public explanation, but industry sources cite wallet-security audit gaps.

đŸ”č Government start date: Federal agencies can issue digital-ruble payments starting 1 Jan 2026 for social security, salaries, and capital expenditure; Ministry of Finance finalising eligible payment types by 31 Dec 2025.

đŸ”č Opt-in mechanism: Recipients (citizens, contractors, civil servants) choose digital ruble ...

🚹 Hong Kong finalizes Basel crypto rules for banks; capital charges kick in 1 Jul 2025 🚹

Hong Kong Monetary Authority (HKMA) published the final “Basel III standardized approach for crypto-asset exposures” on 20 Dec 2024, adopting the global Basel Committee framework with local modifications that enhance disclosure and tighten stablecoin reserve haircuts. The rules—subject to a three-month industry comment period—will be gazetted in March and become mandatory for all locally incorporated banks on 1 July 2025.

🔑Key points

đŸ”č Scope of application: All authorized institutions (AIs) with crypto-asset exposures must classify holdings into Group 1 (tokenized traditional assets) or Group 2 (unbacked crypto); Group 2a (BTC, ETH only) and Group 2b (all others) capital charges differ.

đŸ”č Capital add-ons: Group 2a attracts 1250 % risk-weight (full deduction from CET1) for unhedged positions; Group 2b is flatly prohibited unless held in custody-only mode.

đŸ”č Stablecoin carve-out: Asset-referenced tokens ...

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Stellar CEO Reveals Where Real Opportunity Lies in Crypto Market: Details

In a recent tweet, Stellar Development Foundation (SDF) CEO and Executive Director Denelle Dixon defines what "real opportunity" is in blockchain as a new financial future beckons.

The SDF CEO was reacting to a recent Bloomberg report on Bank of New York Mellon Corp (BNY), Nasdaq, S&P Global and iCapital participation in a new $50 million investment round by Digital Asset Holdings. This comes as some of Wall Street’s biggest names embrace the technology that underpins cryptocurrencies to handle traditional assets.

Reacting to this development, Stellar Foundation CEO Denelle Dixon stated that every blockchain investment is a bet on a different financial future. Dixon added that seeing banks explore blockchain technology validates what has been known over the years.

Real opportunity defined

While Wall Street’s biggest names betting on blockchain might be one of the most significant adoption milestones in the digital asset market, Dixon defines what real opportunity is and what it is not.

According to the SDF executive director, real opportunity is not replicating old systems on new rails but rather building open networks that fundamentally expand global finance participation.

"But the real opportunity isn’t replicating old systems on new rails—it’s building open networks that fundamentally expand who gets to participate in global finance. That’s the opportunity," Dixon tweeted.

At the Meridian 2025 event, Stellar outlined its long-term privacy strategy, committing to investing in critical privacy infrastructure and building foundational cryptographic capabilities.

Stellar eyes privacy upgrade

A new protocol upgrade is on the horizon for the Stellar network: X-Ray, which lays the groundwork for developers to build privacy applications on Stellar using zero-knowledge (ZK) cryptography.

The protocol timeline testnet vote is anticipated for Jan. 7, 2026, while the mainnet vote is expected for Jan. 22, 2026.

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XLM: GDMJF2OCHN3NNNX4T4F6POPBTXK23GTNSNQWUMIVKESTHMQM7XDYAIZT
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XDC Network's acquisition of Contour Network

XDC Network's acquisition of Contour Network marks a silent shift to connect the digital trade infrastructure to real-time, tokenized settlement rails.

In a world where cross-border payments still take days and trap trillions in idle liquidity, integrating Contour’s trade workflows with XDC Network Blockchains' ISO 20022 financial messaging standard to bridge TradFi and Web3 in Trade Finance.

The Current State of Cross-Border Trade Settlements

Cross-border payments remain one of the most inefficient parts of global finance. For decades, companies have inter-dependency with banks and their correspondent banks across the world, forcing them to maintain trillions of dollars in pre-funded nostro and vostro balances — the capital that sits idle while transactions crawl across borders.

Traditional settlement is slow, often 1–5 days, and often with ~2-3% in FX and conversion fees. For every hour a corporation can’t access its own cash increases the cost of financing, tightens liquidity that could be used for other purposes, which in turn slows economic activity.

Before SWIFT, payments were fully manual. Intermediary banks maintained ledgers, and reconciliation across multiple institutions limited speed and volume.

SWIFT reshaped global payments by introducing a secure, standardized messaging infrastructure through ISO 20022 - which quickly became the language of money for 11,000+ institutions in 200 countries.

But SWIFT only fixed the messaging — not the movement. Actual value still moves through slow, capital-intensive correspondent chains.

Regulated and Compliant Stablecoin such as USDC (Circle) solves the part SWIFT never could: instant, on-chain settlement.

Stablecoin Settlement revamping Trade and Tokenization

Stablecoin such as USDC is a digital token pegged to the US Dollar, still the most widely used currency for trade, enabling the movement of funds instantly 24*7 globally - transparently, instantly, and without the need for any intermediaries and the need to lock in trillions of dollars of idle cash.

Tokenized settlement replaces multi-day reconciliation with on-chain finality, reducing:

  • Dependency on intermediaries
  • Operational friction
  • Trillions locked in idle liquidity

For corporates trapped in long working capital cycles, this is transformative.

Digital dollars like USDC make the process simple:

Fiat → Stablecoin → On-Chain Transfer → Fiat

This hybrid model is already widely used across remittances, payouts, and treasury flows.

But one critical piece of global commerce is still lagging:

👉 Trade finance.

The Missing link is still Trade Finance Infrastructure.

While payments innovation has raced ahead, trade finance infrastructure hasn’t kept up. Document flows, letters of credit, and supply-chain financing remain siloed, paper-heavy, and operationally outdated.

This is exactly where the next breakthrough will happen - and why the recent XDC Network acquisition of Contour is a silent revolution.

It transforms to a new era of trade-driven liquidity through an end-to-end digital trade from shipping docs to payment confirmation – one infrastructure that powers all.

The breakthrough won’t come from payments alone — it will come from connecting trade finance to real-time settlement rails.

The XDC + Contour Shift: A Silent Revolution

  • Contour already connects global banks and corporates through digital LCs and digitized trade workflows.
  • XDC Blockchain brings a settlement layer built for speed, tokenization, and institutional-grade interoperability and ISO 20022 messaging compatibility

Contour’s digital letter of credit workflows will be integrated with XDC’s blockchain network to streamline trade documentation and settlement.

Together, they form the first end-to-end digital trade finance network linking:

Documentation → Validation → Settlement all under a single infrastructure.

XDC Ventures (XVC.TECH) is launching a Stable-Coin Lab to work with financial institutions on regulated stablecoin pilots for trade to deepen institutional trade-finance integration through launch of pilots with banks and corporates for regulated stable-coin issuance and settlement.

The Bottom Line

Payments alone won’t transform Global Trade Finance — Trade finance + Tokenized Settlement will.

This is the shift happening underway XDC Network's acquisition of Contour is the quiet catalyst.

Learn how trade finance is being revolutionised:

https://www.reuters.com/press-releases/xdc-ventures-acquires-contour-network-launches-stablecoin-lab-trade-finance-2025-10-22/

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Inside The Deal That Made Polymarket’s Founder One Of The Youngest Billionaires On Earth🌍

One year ago, the FBI raided Polymarket founder Shayne Coplan’s apartment. Now, the college dropout is a billionaire at age 27.

In July, Jeffrey Sprecher, the 70-year-old billionaire CEO of Intercontinental Exchange, the parent company of the New York Stock Exchange, sat at Manhatta, an upscale restaurant in the financial district overlooking the sprawling New York City skyline from the 60th floor. As a sommelier weaved through tables pouring wine, in walked Shayne Coplan—in a T-shirt and jeans, clutching a plastic water bottle and a paper bag with a bagel he’d picked up en route. Sprecher chuckles as he recalls his first impression of the boyish, eccentric entrepreneur: “An old bald guy that works at the New York Stock Exchange, where we require that you wear a suit and tie, next to a mop-headed guy in a T-shirt that's 27.” But Sprecher was fascinated by Polymarket, Coplan’s blockchain-based prediction market, and after dinner, he made his move: “I asked Shayne if he would consider selling us his company.”

Prediction markets like Polymarket let thousands of ordinary people bet on future events—the unemployment rate, say, or when BitCoin will hit an all-time high. In aggregate, prediction market bets have proven to be something of a crystal ball with the wisdom of the crowd often proving itself more prescient than expert opinion. For instance, Polymarket punters predicted that Trump would prevail in the 2024 presidential election, when many national pundits were sure that Kamala Harris would win.

Coplan initially turned down Sprecher’s buyout offer. But discussions led to negotiations and eventually a deal. In October, Intercontinental announced it had invested $2 billion for an up to 25% stake in the company, bringing the young solo founder the balance he was looking for. “We're consumer, we’re viral, we're culture. They’re finance, they’re headless and they’re infrastructure,” Coplan tells Forbes in a recent interview.

At the same time, Coplan announced investments from other billionaires including Figma’s Dylan Field, Zynga’s Mark Pincus, Uber’s Travis Kalanick and hedge fund manager Glenn Dubin. A longtime Red Hot Chili Peppers fan, Coplan even convinced lead singer Anthony Kiedis to invest after a mutual acquaintance brought the musician to Coplan’s apartment one day. “He's buzzing my door, and I’m like, ‘holy shit,'” Coplan recalls, his bright blue eyes widening. “I love their music. A lot of the inspiration [for my work] comes from the music that I listen to.”

Thanks to the deals, Polymarket’s valuation quickly shot to $9 billion, making the 2025 Under 30 alum the world’s youngest self-made billionaire, with an estimated 11% stake worth $1 billion. His reign was short: twenty days later, he was overtaken as the youngest by the three 22-year-old founders of AI startup Mercor.

Young entrepreneurs are minting ten-figure fortunes faster than ever. In addition to the Mercor trio and Coplan, 15 other Under 30 alumni—including ScaleAI cofounder Lucy Guo, Reddit’s Steve Huffman and Cursor’s cofounders—became billionaires this year, while Guo’s cofounder Alexandr Wang and Robinhood’s Vlad Tenev (both former Under 30 honorees) regained their billionaire status after having fallen out of the ranks.

The budding billionaire has long been fascinated by markets and tech. When he was just 14, Coplan emailed the regional Securities and Exchange Commission office to ask how to create new marketplaces. “I did not get a response, but it’s a really funny email,” he says, grinning playfully as he thinks of his younger self. “It just shows that this stuff takes over a decade of percolating in your mind.”

Two years later, Coplan showed up at the offices of internet startup Genius uninvited after multiple emails of his asking for an internship went ignored. At age 16—at least a decade younger than anyone in that office—he secured his first job after making a memorable impression with his “wild curls” and “encyclopedic knowledge of billionaire tech entrepreneurs.” “If he chooses to become a tech entrepreneur, which seems likely, I have no doubt that we’ll be seeing his name again in the press before long,” Chris Glazek, his manager at the time, wrote in Coplan’s college recommendation letter.

Coplan went on to study computer science at NYU, but dropped out in 2017 to work on various crypto projects that never took off. In 2020, he founded Polymarket to create a solution to the “rampant misinformation” he saw in the world: The company’s first market allowed users to bet on when New York City would reopen amid the pandemic. He soon expanded into elections and pop culture happenings, among other events.

But it didn’t take long for the company to butt heads with regulators. In January 2022, Polymarket paid a $1.4 million fine to the Commodity Futures Trading Commission for offering unregistered markets. It was also ordered to block all U.S. users, but activity on Polymarket skyrocketed particularly during the 2024 U.S. presidential election, with bets totaling $3.6 billion. A week after the election, the FBI raided Coplan's apartment and seized his devices as part of an investigation into a possible violation of this agreement. Shortly after, Coplan posted on his X account that he saw the raid as “a last-ditch effort” from the Biden administration “to go after companies they deem to be associated with political opponents.”

In July, the Department of Justice and CFTC dropped the investigations—after which Sprecher reached out to Coplan for dinner—and less than a week later, Polymarket announced it had acquired CFTC-licensed derivatives exchange QCX to prepare for a compliant U.S. launch. QCX applied to be a federally-registered exchange in 2022—an application that was left dormant for three years before receiving approval less than two weeks before the acquisition was announced. When asked about the timing of the deal, Coplan points to CFTC acting chairwoman Caroline Pham, who President Trump tapped to lead the agency in January. “Caroline deserves a lot of credit for getting every single license that had been paused for no reason approved, as acting chairwoman in less than a year,” he says. Coplan had realized an acquisition might be the only way for Polymarket to legally operate in the U.S. as early as 2021 due to the lengthy federal approval process, a source familiar with the deal told Forbes.

Just two months after the acquisition and days after Donald Trump Jr. joined Polymarket’s advisory board, the company received federal approval to launch in the U.S. (Trump Jr. has also served as a strategic advisor to Polymarket’s main competitor Kalshi since January.)

Polymarket’s rapid rise has drawn critics. Dennis Kelleher, co-founder and CEO of Washington-based financial advocacy group Better Markets, told Forbes in an email that the current administration’s deregulation around prediction markets has unlocked a regulatory “loophole” to enable “unregulated gambling” under the CFTC, “which has zero expertise, capacity or resources to regulate and police these markets.” Kelleher added that with backing from the Trump family “who are directly trying to profit on this new gambling den
 the massive deregulation and crypto hysteria will almost certainly end badly for the American people.”

Investors and businesses are scrambling to seize the moment of deregulation. “We had opportunities to invest in events markets earlier, but there was a lot of risk,” Sprecher says, listing the regulatory changes in favor of crypto and prediction markets under the current administration. “This was the moment to invest if we wanted to still be early in the space.”

In the last few months, Trump’s Truth Social and sportsbook FanDuel, as well as cryptocurrency exchanges Crypto.com, Coinbase and Gemini all announced their own plans to offer prediction markets. Robinhood CEO Vlad Tenev said prediction markets, which were integrated into its platform in March, were helping drive record activity for the retail brokerage in its third quarter earnings call.

“People are starting to realize right now that the opportunities are endless,” says Dubin, the billionaire hedge fund veteran who invested in Polymarket earlier this year. He points to sports betting companies, which have been regulated by states as gambling activity and taxed accordingly. States like New York can tax up to 51% of sportsbooks’ revenue, but federally-regulated prediction markets can bypass state laws, avoiding taxes and operating in all 50 states. With the realization that prediction markets could upend the sports betting industry—which brought in $13.7 billion in revenue in 2024—businesses are quickly jumping on board despite pushback from state gambling regulators. In October, both Polymarket and Kalshi secured partnerships with sportsbook PrizePicks and the National Hockey League, and Polymarket announced exclusive partnerships with sportsbook DraftKings and the Ultimate Fighting Championship.

The disruption won’t be limited to sports betting. Alongside its investment, Intercontinental’s tens of thousands of institutional clients including large hedge funds and over 750 third-party providers of data will soon have access to Polymarket data, as it gets integrated into Intercontinental’s products such as indices to better inform investment decisions. It also hopes to work with Polymarket to work on initiatives around tokenization—or converting financial assets into digital tokens on blockchain technology—to allow traders on Intercontinental’s exchanges to trade more flexibly at all hours of the day, Sprecher says. What’s more, in November, Google Finance announced it would integrate Polymarket and Kalshi data into its search results, while Yahoo Finance also announced an exclusive partnership with Polymarket.

Despite flashy investors, partnerships and a record $2.4 billion of trading volume in November, Polymarket has yet to launch in the U.S. or turn a profit. Coplan and his investors have hinted at ways the company could make money one day—selling its data, charging fees to users, launching a cryptocurrency token (similar to Ethereum or Bitcoin)—but decline to confirm any specifics. For now, the only thing that’s certain is the bet Coplan is making on himself. “Going for it and having it not pan out is an infinitely better outcome than living your life as a what if,” he says.

Standing across from the New York Stock Exchange building, Coplan tilts his head up as he watches a massive banner with Polymarket’s logo get hoisted onto the exterior of the building. It’s been five years since founding. One year since the FBI raid. He’s taking it all in. “Against all odds,” the bright blue banner reads, rippling in the wind alongside three American flags protruding from the building.

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